Disrupted Cortical State Regulation in a Rat Model of Fragile X Syndrome
نویسندگان
چکیده
منابع مشابه
Cortical neurogenesis in fragile X syndrome.
The absence of fragile X mental retardation 1 protein (FMRP) results in fragile X syndrome (FXS) that is a common cause of intellectual disability and a variant of autism spectrum disorder. There is evidence that FMRP is involved in neurogenesis. FMRP is widely expressed throughout the embryonic brain development and its expression levels increases during neuronal differentiation. Cortical neur...
متن کاملImpaired inhibitory control of cortical synchronization in fragile X syndrome.
Fragile X syndrome (FXS) is a neurodevelopmental disorder characterized by severe cognitive impairments, sensory hypersensitivity, and comorbidities with autism and epilepsy. Fmr1 knockout (KO) mouse models of FXS exhibit alterations in excitatory and inhibitory neurotransmission, but it is largely unknown how aberrant function of specific neuronal subtypes contributes to these deficits. In thi...
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Objective: Fragile X syndrome is the second etiology for inherited mental retardation. It may concomitant with other psychiatric disorders. Intellectual disability (ID) is a state of functioning that typically begins in childhood and is characterized by limitations in intelligence and adaptive skills. We intend to introduce a male young patient with Fragile X syndrome and Obsessive-Compulsive d...
متن کاملErratum: Sensory hypo-excitability in a rat model of fetal development in Fragile X Syndrome
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متن کاملSensory hypo-excitability in a rat model of fetal development in Fragile X Syndrome
Fragile X syndrome (FXS) is characterized by sensory hyper-sensitivity, and animal models suggest that neuronal hyper-excitability contributes to this phenotype. To understand how sensory dysfunction develops in FXS, we used the rat model (FMR-KO) to quantify the maturation of cortical visual responses from the onset of responsiveness prior to eye-opening, through age equivalents of human juven...
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ژورنال
عنوان ژورنال: Cerebral Cortex
سال: 2016
ISSN: 1047-3211,1460-2199
DOI: 10.1093/cercor/bhv331